In the campaign of Medal of Honor (2010), the A-10 Warthog is utilized by the United States Air Force, providing danger-close close air support fire on insurgent positions in and around Bagram Airfield.
The A-10 is available in the form of a support action in the game's multiplayer. When a target is marked, two A10s strafe the designated area (too fast to be damaged by any weapon) with their main 30mm cannons. It is capable of neutralizing any light hostile in a decently sized blast radius of the target.
- "A-10 gun run supports are devastating on enemy positions, capable of laying down a barrage of cannon fire the extent of the combat area. Operators thus need to designate targets carefully so pilots can orient themselves for ideal fire solutions."
- — Description
The A-10 Thunderbolt II is seen during the E3 Multiplayer Reveal Trailer, where it is shown shooting down a large tower.
In-game, the A-10 Thunderbolt II, called A-10 Warthog in-game, appears as the Tier 3 Offensive Support Action for the Spec Ops multiplayer class. It is identical to the Strafing Run in the previous game, but only consists of one A-10.